ActivatedĬharcoal normally provides adequate gastrointestinalĭecontamination. Ingestion of other CNS depressants and other drugs. It should be remembered thatīenzodiazepine ingestions by adults commonly involve co. 2.4 First aid measures and management principles Most benzodiazepine poisonings require only clinical Overdose, but administration of this drug is rarely This information mayĬonfirm the diagnosis but is not useful in the clinicalĪ clinical response to flumazenil, a specific benzodiazepineĪntagonist, also confirms the diagnosis of benzodiazepine 2.3 Diagnosis The clinical diagnosis is based upon the history ofīenzodiazepine overdose and the presence of the clinicalīenzodiazepines can be detected or measured in blood and The amnesia produced byīenzodiazepines can have medico-legal consequences. Ifīenzodiazepines are discontinued abruptly after regular use, IntravenousĪdministration of even therapeutic doses of benzodiazepinesĭependence may develop with regular use of benzodiazepines,Įven in therapeutic doses for short periods. More susceptible to the CNS depressant action. Ingestion of other CNS depressants, which act synergistically Overdose in adults frequently involves co. Impairment are the most common adverse effects ofīenzodiazepines. Somnolence, diplopia, dysarthria, ataxia and intellectual Manifestations of severe CNS depression are rare. Paradoxical excitation, but deaths are rare whenīenzodiazepines are taken alone. 2.2 Summary of clinical effects Central nervous system (CNS) depression and coma, or SUMMARY 2.1 Main risks and target organs Central nervous system, causing depression of NAME 1.1 Substance Benzodiazepines 1.2 Group Alprazolam Bromazepam Brotizolam Camazepam Chlordiazepoxide Cinolazepam Clobazam Clonazepam Clorazepate Clotiazepam Cloxazolam Diazepam Doxefazepam Estazolam Etizolam Flunitrazepam Halazepam Haloxazolam Ketazolam Loprazolam Lorazepam Lormetazepam Medazepam Mexazolam Midazolam Nitrazepam Nordazepam Oxazolam Oxazepam Pinazepam Prazepam Quazepam Temazepam Tetrazepam Tofisopam Triazolam 1.3 Synonyms 1.4 Identification numbers 1.4.1 CAS numberīenzodiazepine derivatives (N05BA) 1.5 Main brand names, main trade names 1.6 Main manufacturers, main importers 2. Poisons Information Monograph (Group monograph) G008ġ. International Programme on Chemical Safety AUTHOR(S), REVIEWER(S), DATE(S) (INCLUDING UPDATES), COMPLETE ADDRESS(ES) TOXICOLOGICAL ANALYSES AND BIOMEDICAL INVESTIGATIONSĨ.1.2 Storage of laboratory samples and specimensĨ.1.3 Transport of laboratory samples and specimensĨ.2 Toxicological Analyses and Their InterpretationĨ.2.1 Tests on toxic ingredient(s) of materialĨ.2.1.2 Advanced Qualitative Confirmation Test(s)Ĩ.2.2.2 Advanced Qualitative Confirmation Test(s)Ĩ.2.3 Interpretation of toxicological analysesĨ.3 Biomedical investigations and their interpretationĨ.3.4 Interpretation of biomedical investigationsĨ.4 Other biomedical (diagnostic) investigations and their interpretationĨ.5 Overall interpretation of all toxicological analyses and toxicological investigationsĩ.4 Systematic description of clinical effectsĩ.4.9 Eye, ear, nose, throat: local effectsĩ.4.12.2 Fluid and electrolyte disturbancesġ0.2 Life supportive procedures and symptomatic/specific treatmentġ4. NAMEĢ.4 First aid measures and management principlesĦ.3 Biological half-life by route of exposureĨ. Benzodiazepines (PIM G008) Benzodiazepines 1.
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